2-Hydroxy-5-(3,5,7-trihydroxy-4-oxo-4H-chromen-2-yl)phenyl (E)-3-(4-hydroxy-3-methoxyphenyl)acrylate: Synthesis, In Silico Analysis and In Vitro Pharmacological Evaluation

Quercetin and ferulic acid are two phytochemicals extensively represented in the plant kingdom daily consumed considerable amounts through diets. Due to a common phenolic structure, these molecules share several pharmacological properties, e.g., antioxidant free radical scavenging, anti-cancer, anti-inflammatory, anti-arrhythmic, vasorelaxant. The aim of present work was combination single chemical entity, conceivably endowed with more efficacious vasorelaxant activity. Preliminary silico studies herein described suggested that new hybrid compound bound spontaneously high affinity on KCa1.1 channel. Thus, synthesis 3′-ferulic ester derivative quercetin achieved its structure confirmed by 1H- 13C-NMR spectra, HSQC HMBC experiments, mass spectrometry, elementary analysis. effect vascular CaV1.2 channels revealed partial loss stimulatory activity characterizes parent quercetin. Therefore, further necessary identify better strategy improve properties this flavonoid.